In an effort to avoid paying off a massive gambling debt to notorious mobster Irina (Maggie Q) in England, British couple Harriet (Uma Thurman) and Peter Fox (Tim Roth) flee to Los Angeles in order to steal a priceless jewel from Peter's actress ex-wife, Jackie (Alice Eve).
Along the way, we meet other eccentric characters, including a pedophile priest (Stephen Fry) who's connected in the underworld, Jackie's abusive fiancé Gabriel (Crispin Glover), Gabriel's suffering personal assistant Gina (Parker Posey), and Vivien (Sofía Vergara) – the star of Gabriel's latest film.