In the not-too-distant future there is widespread famine; armies have been disbanded and life has regressed into farm-based economies. The Earth's atmosphere has become rich in nitrogen but poor in oxygen, and soon global starvation will give way to global asphyxiation.
Cooper (Matthew McConaughey), a widower, is a former NASA test pilot who still dreams of flight. He and his two children, Tom (Timothée Chalamet), 15, and Murphy (Mackenzie Foy), 10, struggle to survive.
Meanwhile, Professor Brand (Michael Caine), a brilliant physicist, and his team, including his scientist daughter (Anne Hathaway) have two potential plans to save mankind, but only one involves saving the six-billion plus people on Earth.