Genetics professor Don Tillman finds it difficult to fit in with others and has an unsatisfying romantic life as a result. He comes up with the idea of the Wife Project, an in-depth questionnaire that will determine whether someone is his perfect mate.
His friend introduces him to Rosie, who definitely does not meet his project's criteria, but he finds himself drawn to the unorthodox woman. While not perfect on paper, Rosie may soon prove to be exactly what Don needs in his otherwise organized and efficient life.
Based on the bestselling book of the same name by Australian novelist Graeme Simsion, which was named "Book of the Year for 2014" by the Australian Book Industry Association.