Lon Chaney Jr.
as Lennie
Charles Bickford
as Slim
Burgess Meredith
as George
Betty Field
as Mae
Roman Bohnen
as Candy
Bob Steele
as Curley
Noah Beery Jr.
as Whit
Oscar O'Shea
as Jackson
Granville Bates
as Carlson
Leigh Whipper
as Crooks
Helen Lynd
as Susie
Barbara Pepper
as Girl (uncredited)
Henriette Kay
as Girl (uncredited)
Eddie Dunn
as Bus Driver (uncredited)